Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.

• Главные авторы: Alexandra eLazar (Автор), Nora eLenkey (Автор), Krisztina ePesti (Автор), Laszlo eFodor (Автор), Arpad eMike (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2015-09-01T00:00:00Z.
• Предметы: article
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The major drug binding site of sodium channels is inaccessible from the extracellular side, drug molecules can only access it either from the membrane phase, or from the intracellular aqueous phase. For this reason, ligand-membrane interactions are as important determinants of inhibitor properties,...