Effect of Apium graveolens Extract Administration on the Pharmacokinetics of Captopril in the Plasma of Rats

Apium graveolens (celery) is an edible and traditionally medicinal plant that is used worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive drugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the study is to assess th...

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Main Authors: Siska Siska (Author), Abdul Mun`im (Author), Anton Bahtiar (Author), Franciscus D. Suyatna (Author)
Format: Book
Published: MDPI AG, 2018-02-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Siska Siska  |e author 
700 1 0 |a Abdul Mun`im  |e author 
700 1 0 |a Anton Bahtiar  |e author 
700 1 0 |a Franciscus D. Suyatna  |e author 
245 0 0 |a Effect of Apium graveolens Extract Administration on the Pharmacokinetics of Captopril in the Plasma of Rats 
260 |b MDPI AG,   |c 2018-02-01T00:00:00Z. 
500 |a 2218-0532 
500 |a 10.3390/scipharm86010006 
520 |a Apium graveolens (celery) is an edible and traditionally medicinal plant that is used worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive drugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the study is to assess the effects of administrating the celery extract on captopril pharmacokinetics. Sprague-Dawley strain rats were divided into two groups (n = 6). Group I was given captopril (10 mg/kg Body Weight (BW)) orally, while Group II was pretreated with celery extract orally (40 mg/kg BW) an hour before administration of captopril. The blood samples were withdrawn at various intervals after drug administration. The captopril concentration was determined using liquid chromatography-mass spectrometry (LC-MS/MS) and from the blood data, the values of Ke, Cmax, Tmax, T1/2, and area under the curve (AUC) were calculated. The results showed that oral administration of the celery extract increased Cmax (38.67%), T1/2 (37.84%), and AUC (58.10%) and decreased Ke (27.45%) of captopril in Group II (celery + captopril) compared with Group I (captopril). In conclusion, celery extract can alter the pharmacokinetic of captopril when given in combination. The combination might be beneficial for the treatment of hypertension, as celery causes an increase in the plasma level of captopril, which can enhance its efficacy. 
546 |a EN 
690 |a Apium graveolens 
690 |a captopril 
690 |a celery extracts 
690 |a pharmacokinetics 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Scientia Pharmaceutica, Vol 86, Iss 1, p 6 (2018) 
787 0 |n http://www.mdpi.com/2218-0532/86/1/6 
787 0 |n https://doaj.org/toc/2218-0532 
856 4 1 |u https://doaj.org/article/a5086cfaf8a547c992073c649ff7fa6f  |z Connect to this object online.