Labor epidural analgesia and risk of autism Spectrum disorders in offspring: A systematic review and meta-analysis

BackgroundThe effect of labor epidural anesthesia (LEA) on the risk of autism spectrum disorder (ASD) in offspring has been investigated recently, and available results are inconsistent.MethodsWe searched the PubMed and EMBASE databases for relevant studies and performed a systematic review and meta...

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Main Authors: Ling-ling Fang (Author), Yuan-yue Zhou (Author), Hai-yin Jiang (Author), Yu-dan Shi (Author)
Format: Book
Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Ling-ling Fang  |e author 
700 1 0 |a Yuan-yue Zhou  |e author 
700 1 0 |a Hai-yin Jiang  |e author 
700 1 0 |a Yu-dan Shi  |e author 
245 0 0 |a Labor epidural analgesia and risk of autism Spectrum disorders in offspring: A systematic review and meta-analysis 
260 |b Frontiers Media S.A.,   |c 2023-02-01T00:00:00Z. 
500 |a 2296-2360 
500 |a 10.3389/fped.2022.965205 
520 |a BackgroundThe effect of labor epidural anesthesia (LEA) on the risk of autism spectrum disorder (ASD) in offspring has been investigated recently, and available results are inconsistent.MethodsWe searched the PubMed and EMBASE databases for relevant studies and performed a systematic review and meta-analysis of the literature. Subgroup analyses were conducted to assess the sources of heterogeneity. Both fixed and random effects models were used was used to estimate overall relative risk.ResultsOur results showed that LEA was associated with an increased risk of ASD in offspring [HR = 1.3, 95% confidence interval (CI): 1.25-1.35; P < 0.001] after combining crude estimates from the included studies. This association was gradually reduced, but still statistically significant, when potential confounding factors were considered (HR 1.13, 95% CI 1.03-1.25, P = 0.014). However, there was no significant association when we combined data of siblings from other pregnancies (HR = 1.07, 95% CI: 0.99-1.16, P = 0.076), implying that the association was due to confounding factors.ConclusionThe statistically significant association between LEA and ASD in the offspring can be partially explained by unmeasured confounding.Systematic Review RegistrationIdentifier CRD42022302892. 
546 |a EN 
690 |a neurodevelopment 
690 |a pain 
690 |a children 
690 |a meta-analysis 
690 |a analgesia 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pediatrics, Vol 10 (2023) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fped.2022.965205/full 
787 0 |n https://doaj.org/toc/2296-2360 
856 4 1 |u https://doaj.org/article/a554b01a57e24e7f82ef9cebf848874d  |z Connect to this object online.