Synthesis, Physicochemical Characteristics and Plausible Mechanism of Action of an Immunosuppressive Isoxazolo[5,4-e]-1,2,4-Triazepine Derivative (RM33)

• Main Authors: Marcin Mączyński (Author), Andrzej Regiec (Author), Aleksandra Sochacka-Ćwikła (Author), Iwona Kochanowska (Author), Maja Kocięba (Author), Ewa Zaczyńska (Author), Jolanta Artym (Author), Wojciech Kałas (Author), Michał Zimecki (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies demonstrated strong anti-inflammatory properties of isoxazolo[5,4-e]-1,2,4-triazepine (RM33) in vivo. The aim of this investigation was to describe synthesis, determine physicochemical characteristics, evaluate biological activities in murine and human in vitro models, as well as to...