Protective Effect of Anthocyanin-Enriched Polyphenols from <i>Hibiscus syriacus</i> L. (Malvaceae) against Ultraviolet B-Induced Damage

• Main Authors: Wisurumuni Arachchilage Hasitha Maduranga Karunarathne (Author), Ilandarage Menu Neelaka Molagoda (Author), Kyoung Tae Lee (Author), Yung Hyun Choi (Author), Sang-Mi Yu (Author), Chang-Hee Kang (Author), Gi-Young Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Anthocyanin-enriched polyphenols from the flower petals of <i>H. syriacus</i> L. (Malvaceae, AHs) possess anti-septic shock, anti-oxidant, and anti-melanogenic properties. However, whether AHs positively or negatively regulate ultraviolet B (UVB)-mediated photoaging and photodamage remains unclear. This study aims to investigate the protective effect of AHs against UVB-induced damage. We examined the photoprotective effects of AHs on UVB-induced apoptosis, endoplasmic reticulum (ER) stress, and mitochondrial reactive oxygen species (mtROS). AHs prevented UVB irradiation-induced apoptosis of HaCaT keratinocytes by inhibiting caspase activation and ROS production. Moreover, AHs restored the survival rate and the hatchability of UVB-irradiated zebrafish larvae without any abnormalities. Furthermore, AHs inhibited UVB-induced ER stress, resulting in a decrease in mtROS production via the stabilization of the mitochondrial membrane potential. Our results indicate that AHs inhibit UVB-induced apoptosis by downregulating total cytosolic ROof cytosolic CaS and ER-mediated mitoROS production in both HaCaT keratinocytes and zebrafish larvae. These findings provide evidence for the applications of AHs to protect skin from UVB-induced photodamage.

Item Description

10.3390/antiox10040584
2076-3921