Protective Effect of Anthocyanin-Enriched Polyphenols from <i>Hibiscus syriacus</i> L. (Malvaceae) against Ultraviolet B-Induced Damage
Anthocyanin-enriched polyphenols from the flower petals of <i>H. syriacus</i> L. (Malvaceae, AHs) possess anti-septic shock, anti-oxidant, and anti-melanogenic properties. However, whether AHs positively or negatively regulate ultraviolet B (UVB)-mediated photoaging and photodamage remai...
Sparad:
| Huvudupphovsmän: | , , , , , , |
|---|---|
| Materialtyp: | Bok |
| Publicerad: |
MDPI AG,
2021-04-01T00:00:00Z.
|
| Ämnen: | |
| Länkar: | Connect to this object online. |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_a55acb24c2a24afaa9232afbeb4e96d4 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Wisurumuni Arachchilage Hasitha Maduranga Karunarathne |e author |
| 700 | 1 | 0 | |a Ilandarage Menu Neelaka Molagoda |e author |
| 700 | 1 | 0 | |a Kyoung Tae Lee |e author |
| 700 | 1 | 0 | |a Yung Hyun Choi |e author |
| 700 | 1 | 0 | |a Sang-Mi Yu |e author |
| 700 | 1 | 0 | |a Chang-Hee Kang |e author |
| 700 | 1 | 0 | |a Gi-Young Kim |e author |
| 245 | 0 | 0 | |a Protective Effect of Anthocyanin-Enriched Polyphenols from <i>Hibiscus syriacus</i> L. (Malvaceae) against Ultraviolet B-Induced Damage |
| 260 | |b MDPI AG, |c 2021-04-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox10040584 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a Anthocyanin-enriched polyphenols from the flower petals of <i>H. syriacus</i> L. (Malvaceae, AHs) possess anti-septic shock, anti-oxidant, and anti-melanogenic properties. However, whether AHs positively or negatively regulate ultraviolet B (UVB)-mediated photoaging and photodamage remains unclear. This study aims to investigate the protective effect of AHs against UVB-induced damage. We examined the photoprotective effects of AHs on UVB-induced apoptosis, endoplasmic reticulum (ER) stress, and mitochondrial reactive oxygen species (mtROS). AHs prevented UVB irradiation-induced apoptosis of HaCaT keratinocytes by inhibiting caspase activation and ROS production. Moreover, AHs restored the survival rate and the hatchability of UVB-irradiated zebrafish larvae without any abnormalities. Furthermore, AHs inhibited UVB-induced ER stress, resulting in a decrease in mtROS production via the stabilization of the mitochondrial membrane potential. Our results indicate that AHs inhibit UVB-induced apoptosis by downregulating total cytosolic ROof cytosolic CaS and ER-mediated mitoROS production in both HaCaT keratinocytes and zebrafish larvae. These findings provide evidence for the applications of AHs to protect skin from UVB-induced photodamage. | ||
| 546 | |a EN | ||
| 690 | |a <i>Hibiscus syriacus</i> L. (Malvaceae) | ||
| 690 | |a ultraviolet B | ||
| 690 | |a reactive oxygen species | ||
| 690 | |a endoplasmic reticulum | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 10, Iss 4, p 584 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/10/4/584 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a55acb24c2a24afaa9232afbeb4e96d4 |z Connect to this object online. |