Drying Behavior and Kinetics of Drying Process of Plant-Based Enteric Hard Capsules

• Main Authors: Chuqi He (Author), Haodong Wang (Author), Yucheng Yang (Author), Yayan Huang (Author), Xueqin Zhang (Author), Moses Arowo (Author), Jing Ye (Author), Na Zhang (Author), Meitian Xiao (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/pharmaceutics13030335; 1999-4923
• Keywords: plant-based enteric hard capsules; hot-air drying; drying characteristics; modeling; Pharmacy and materia medica; RS1-441
• Source: Pharmaceutics, Vol 13, Iss 3, p 335 (2021)

The drying process is a significant step in the manufacturing process of enteric hard capsules, which affects the physical and chemical properties of the capsules. Thus, the drying characteristics of plant-based enteric hard capsules were investigated at a constant air velocity of 2 m/s in a bench scale hot-air dryer under a temperature range of 25 to 45 °C and relative humidity of 40 to 80%. Results indicate that the drying process of the capsules mainly occur in a falling-rate period, implying that moisture transfer in the capsules is governed by internal moisture diffusion rate. High temperature and low relative humidity reduce drying time but increase the drying rate of the capsules. Investigation results of the mechanical properties and storage stability of the capsules, however, reveal that a fast drying rate leads to plant-based enteric hard capsules of low quality. Scanning electron microscopy further demonstrates that more layered cracks appear in capsules produced under a faster drying rate. The Page model yielded the best fit for describing thin-layer drying of the capsules based on the coefficient of determination and reduced chi-square. Moreover, it was established that the effective moisture diffusivity of the capsules increases with an increase in drying temperature or reduction in relative humidity.