Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2013-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock. Keywords:: circadian clock, serotonin, non-photic |
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| Item Description: | 1347-8613 10.1254/jphs.13170SC |