Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

• প্রধান লেখক: Asmaa E. Kassab (Author), Ehab M. Gedawy (Author), Mohammed I. A. Hamed (Author), Ahmed S. Doghish (Author), Rasha A. Hassan (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Novel tolmetin derivatives 5a-f to 8a-c were designed, synthesised, and evaluated for antiproliferative activity by NCI (USA) against a panel of 60 tumour cell lines. The cytotoxic activity of the most active tolmetin derivatives 5b and 5c was examined against HL-60, HCT-15, and UO-31 tumour cell li...