RELATIONSHIPS BETWEEN GINGIVAL FIBROBLASTS AND NUR77-ACTIVATED PRO-B LYMPHOCYTES

Aim of the study We explored the relationships between the gingival fibroblasts and pro-B lymphocytes apoptosis in vitro because the current medical literature is lacking such data. Material and methods The aim of our study was represented by the effects of gingival fibroblasts on the apoptosis of N...

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Main Authors: Carmen (Amititeloaie) (Author), Roxana Irina Iancu (Author), Geanina Bogza (Author), Liliana Chelaru (Author), Marcel Costuleanu (Author), Decebal Vasincu (Author)
Format: Book
Published: Romanian Society of Oral Rehabilitation, 2020-04-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Carmen   |q  (Amititeloaie)   |e author 
700 1 0 |a Roxana Irina Iancu  |e author 
700 1 0 |a Geanina Bogza   |e author 
700 1 0 |a Liliana Chelaru  |e author 
700 1 0 |a Marcel Costuleanu  |e author 
700 1 0 |a Decebal Vasincu  |e author 
245 0 0 |a RELATIONSHIPS BETWEEN GINGIVAL FIBROBLASTS AND NUR77-ACTIVATED PRO-B LYMPHOCYTES 
260 |b Romanian Society of Oral Rehabilitation,   |c 2020-04-01T00:00:00Z. 
500 |a 2066-7000 
500 |a 2601-4661 
520 |a Aim of the study We explored the relationships between the gingival fibroblasts and pro-B lymphocytes apoptosis in vitro because the current medical literature is lacking such data. Material and methods The aim of our study was represented by the effects of gingival fibroblasts on the apoptosis of Nur77 receptors-activated pro-lymphocytes in vitro, also in the presence of some retinoid derivatives. Gingival fibroblasts were obtained from male rats. Pro-B cells of murine type in cultures were used for actual experiments. The apoptosis of pro-B cells was induced using a combination of cytosporone B (50 µM) and cyclosporine A (1 µM). The apoptotic effects were revealed using the classical flow cytometry techniques. Results We clearly showed that pro-B lymphocyte apoptosis induced by the combination of cytosporone B (Nur77 agonist) and cyclosporine A in the presence of gingival fibroblasts could be slightly reduced by 13-cis retinoic acid. The inhibitory effects of 13-cis retinoic acid were powerful than those of tazarotenic acid. The effects of 13-cis retinoic acid and tazarotenic acid were evaluated toward the effects of the combination of cytosporone B and cyclosporine A. Conclusions The intrinsic pathways of retinoid derivatives remain to be established by further experiments 
546 |a EN 
690 |a 13-cis retinoic acid 
690 |a cyclosporine a 
690 |a cytosporone b 
690 |a gingival fibroblast 
690 |a nur77 
690 |a pro-b lymphocyte 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Romanian Journal of Oral Rehabilitation, Vol 12, Iss 1, Pp 59-64 (2020) 
787 0 |n http://www.rjor.ro/relationships-between-gingival-fibroblasts-and-nur77-activated-pro-b-lymphocytes/ 
787 0 |n https://doaj.org/toc/2066-7000 
787 0 |n https://doaj.org/toc/2601-4661 
856 4 1 |u https://doaj.org/article/a5dff77830884574910a4e517b504b15  |z Connect to this object online.