DnaG Primase-A Target for the Development of Novel Antibacterial Agents

• Main Authors: Stefan Ilic (Author), Shira Cohen (Author), Meenakshi Singh (Author), Benjamin Tam (Author), Adi Dayan (Author), Barak Akabayov (Author)
• Format: Book
• Published: MDPI AG, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bacterial primase—an essential component in the replisome—is a promising but underexploited target for novel antibiotic drugs. Bacterial primases have a markedly different structure than the human primase. Inhibition of primase activity is expected to selectively halt bacteri...