Analysis of single-cell RNA sequencing in human oocytes with diminished ovarian reserve uncovers mitochondrial dysregulation and translation deficiency

• Main Authors: Xin Li (Author), Xingwu Wu (Author), Hui Zhang (Author), Peipei Liu (Author), Leizhen Xia (Author), Nana Zhang (Author), Lifeng Tian (Author), Zengming Li (Author), Jing Lu (Author), Yan Zhao (Author), Jun Tan (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Diminished ovarian reserve (DOR) is clinically characterized by a decrease in the number of available ovarian follicles and a decline in the quality of oocytes, accompanied by hormonal changes. Low quality of DOR oocyte leads to impaired embryo development, an increased risk of a...