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Targeting interleukin-10 signalling for cancer immunotherapy, a promising and complicated task

Interleukin 10 (IL-10) belongs to IL-10 family cytokines that are critical for maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing excessive immune responses to damage self. Temporal IL-10 signaling blockade enhances vaccine-induced tumor regression by CD...

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Main Authors: Guoying Ni (Author), Lu Zhang (Author), Xiaodan Yang (Author), Hejie Li (Author), Bowei Ma (Author), Shelley Walton (Author), Xiaolian Wu (Author), Jianwei Yuan (Author), Tianfang Wang (Author), Xiaosong Liu (Author)
Format: Book
Published: Taylor & Francis Group, 2020-10-01T00:00:00Z.
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Summary:Interleukin 10 (IL-10) belongs to IL-10 family cytokines that are critical for maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing excessive immune responses to damage self. Temporal IL-10 signaling blockade enhances vaccine-induced tumor regression by CD8 + T cells. IL-10, especially pegylated IL-10, mediates tumor regression by expanding tumor-infiltrating CD8 + T cells. Moreover, targeting IL-10 enhances immune checkpoint inhibitor mediated tumor regression. In the current paper, we will review recent advances in this area and discuss the complexity of IL-10 manipulation for cancer therapy.
Item Description:2164-5515
2164-554X
10.1080/21645515.2020.1717185

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