HIV and Hepatitis B seroprevalence among the nepalese blood donors

• Main Authors: SR Kandel (Author), P Ghimire (Author), BR Tiwari (Author), M Rajkarnikar (Author)
• Format: Book
• Published: Association of Clinical Pathologists of Nepal, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2091-0797; 2091-0908; 10.3126/jpn.v3i5.7864
• Keywords: Blood Donors; ELISA; HIV; HBsAg; Seroprevalence; Pathology; RB1-214
• Source: Journal of Pathology of Nepal, Vol 3, Iss 5, Pp 390-393 (2013)

<p><strong>Background: </strong>HIV and Hepatitis B infections are public health problems in Nepal. This study was conducted based at NRCS/CBTS, with the objective of determining the HIV and HBsAg sero-prevalence in non-remunerated volunteer blood donors.</p> <p><strong>Materials and Methods: </strong>A total of 66,904 units of blood collected, following donor recruitment criteriaduring March 2009-Sept. 2010 was included for analysis. All donated blood samples were subjected to screening for Transfusion transmitted infections including HIV and Hepatitis B surface antigen using standard ELISA test kits (Dade Behring, Germany). Initial reactive sera were re-tested for reconfi rmation with same test kits plus another test kit (Detect-HIV, Adaltis Inc, and Qualisa).</p> <p><strong>Results: </strong>Out of 66,904 units of blood collected, 56,973 units were from male and 9,931 were from female donors. Among the total screened samples, 73 (0.10%) were found to be positive for HIV, {0.11% (64/56973) in male and 0.09% (9/9931) in female}; the difference between male and female donors (?2<3.841) was statistically signifi cant. The seroprevalence of HIV was highest in age group of 30- 39 both in male and female (p<0.001). Similarly, for HBsAg, overall seroprevalence was found to be 0.47% (316/66904 {0.42% (242/56973) in male and 0.74% (74/9931) in female}. The difference was statistically signifi cant (?2<3.841). The highest HBsAg sero-prevalence(0.65%) was also observed in same age group i.e. 30-39 (p<0.001) in male but highest seroprevalence (2.63%) was observed inage group of ?50 in female.</p> <p><strong>Conclusion: </strong>Both HIV and HBV sero-prevalence is high in adult voluntary blood donors.</p> <p>Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 390-393</p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v3i5.7864">http://dx.doi.org/10.3126/jpn.v3i5.7864</a></p>