Controlling the Solubility, Release Rate and Permeation of Riluzole with Cyclodextrins
Riluzole (RLZ), a sodium channel-blocking benzothiazole anticonvulsant BCS class II drug, is very slightly soluble in aqueous medium. To improve aqueous solubility and modulate dissolution rate and membrane permeability, complex formation of RLZ with two cyclodextrin, α-cyclodextrin (α-CD) and sulfo...
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| Main Authors: | , , |
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| Format: | Book |
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MDPI AG,
2024-06-01T00:00:00Z.
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