Adaptation of a human gut epithelial model in relation to the assessment of clinical pharmacokinetic parameters for selected tyrosine kinase inhibitors
The absorption, efflux and transport properties of two of the most commonly used tyrosine kinase inhibitors (TKIs), Erlotinib (E) and Gefitinib (G) were investigated using an adapted workable methodology of a 3-day Caco-2 cell monolayer transwell system, a standard model to test drug permeability an...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
International Association of Physical Chemists (IAPC),
2015-03-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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