Population pharmacokinetics and exposure-response analyses of varenicline in adolescent smokers

• Main Authors: Daryl J. Fediuk (Author), Kevin Sweeney (Author), Vaishali Sahasrabudhe (Author), Thomas McRae (Author), Wonkyung Byon (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Varenicline is an approved smoking cessation aid in adults. Population pharmacokinetics (popPK) and exposure-response (ER) (continuous abstinence rates [CAR] weeks 9‒12 and nausea/vomiting incidence) for varenicline in adolescent smokers were characterized using data from two phase 1 and on...