Indoleamine 2,3-dioxygenase 1 promotes osteosarcoma progression by regulating tumor-derived exosomal miRNA hsa-miR-23a-3p

• Main Authors: Dan Yang (Author), Yinxian Chen (Author), Zhen Ning Tony He (Author), Yichen Wang (Author), Chenghui Ke (Author), Yi Luo (Author), Sun Wang (Author), Qichao Ma (Author), Mengjie Chen (Author), Qing Yang (Author), Ziming Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Osteosarcoma (OS) is the most common primary malignant tumor originating in bone. Immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) participates in tumor immune tolerance and promotes tumor progression, while the study of IDO1 in OS is limited.Methods: Immunohistochemistry an...