Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis

Polybutylene succinate (PBS) is a biodegradable polyester with better processability and different mechanical properties compared to polylactides (PLAs), the most commonly used synthetic polymers in tissue engineering (TE). Since only few studies have evaluated PBS-containing materials for bone TE,...

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Main Authors: Miina Ojansivu (Author), Laura Johansson (Author), Sari Vanhatupa (Author), Ilmari Tamminen (Author), Markus Hannula (Author), Jari Hyttinen (Author), Minna Kellomäki (Author), Susanna Miettinen (Author)
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Published: Hindawi Limited, 2018-01-01T00:00:00Z.
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100 1 0 |a Miina Ojansivu  |e author 
700 1 0 |a Laura Johansson  |e author 
700 1 0 |a Sari Vanhatupa  |e author 
700 1 0 |a Ilmari Tamminen  |e author 
700 1 0 |a Markus Hannula  |e author 
700 1 0 |a Jari Hyttinen  |e author 
700 1 0 |a Minna Kellomäki  |e author 
700 1 0 |a Susanna Miettinen  |e author 
245 0 0 |a Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis 
260 |b Hindawi Limited,   |c 2018-01-01T00:00:00Z. 
500 |a 1687-966X 
500 |a 1687-9678 
500 |a 10.1155/2018/5928935 
520 |a Polybutylene succinate (PBS) is a biodegradable polyester with better processability and different mechanical properties compared to polylactides (PLAs), the most commonly used synthetic polymers in tissue engineering (TE). Since only few studies have evaluated PBS-containing materials for bone TE, we prepared PLA-PBS blends and analyzed material properties as well as cell attachment, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs) on scaffolds. In addition to PLA, PBS, and PLA-PBS blends, PLA-polycaprolactone and PLA-poly(trimethylene carbonate) blends were evaluated. Polymer fibers were prepared using melt spinning. Pure PBS was observed to have the highest crystallinity and strain at break compared to the tougher PLA and PLA blends. No degradation occurred during the 4-week hydrolysis in either of the materials. Knitted and rolled scaffolds were manufactured, seeded with hMSCs, and cultured for 27 days. Human MSC viability was good on all the materials, but cell spreading along the fibers was only detected in PBS-containing scaffolds. They also induced the strongest proliferative response and osteogenic differentiation, which diminished with decreasing PBS content. Based on these results, PBS is superior to PLA with respect to hMSC attachment, proliferation, and osteogenesis. This encourages utilizing PBS-based biomaterials more widely in bone TE applications. 
546 |a EN 
690 |a Internal medicine 
690 |a RC31-1245 
655 7 |a article  |2 local 
786 0 |n Stem Cells International, Vol 2018 (2018) 
787 0 |n http://dx.doi.org/10.1155/2018/5928935 
787 0 |n https://doaj.org/toc/1687-966X 
787 0 |n https://doaj.org/toc/1687-9678 
856 4 1 |u https://doaj.org/article/a6d65d4e0bcc49b59f1cb05e0ef40b10  |z Connect to this object online.