Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

• Main Authors: Muhammad Erfan Uddin (Author), Dominique A. Garrison (Author), Kyeongmin Kim (Author), Yan Jin (Author), Eric D. Eisenmann (Author), Kevin M. Huang (Author), Alice A. Gibson (Author), Zeping Hu (Author), Alex Sparreboom (Author), Shuiying Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic cation transporter 1 (OCT1) is a transporter that regulates the hepatic uptake and subsequent elimination of diverse cationic compounds. Although OCT1 has been involved in drug-drug interactions and causes pharmacokinetic variability of many prescription drugs, details of the molecular mecha...