The role of Interleukin-12 in immune-mediated rheumatic diseases

• Main Authors: A. Spadaro (Author), R. Scrivo (Author), T. Rinaldi (Author), V. Riccieri (Author), A. Sili Scavalli (Author), E. Taccari (Author), G. Valesini (Author)
• Format: Book
• Published: PAGEPress Publications, 2002-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: IL-12 is a proinflammatory cytokine produced by different antigen presenting cells. It has been shown to exert a critical role in inducing Th1 phenotype, thus initiating cell-mediated immune responses, but the significance of IL-12 in rheumatic diseases is not clear. Aim of the study was...