Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability
In cystic fibrosis, the most common disease-causing mutation is F508del, which causes not only intracellular retention and degradation of CFTR, but also defective channel gating and decreased membrane stability of the small amount that reaches the plasma membrane (PM). Thus, pharmacological correcti...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2019-06-01T00:00:00Z.
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