Arterial Stiffness is an Independent Risk Factor for Anemia After Percutaneous Native Kidney Biopsy

• Main Authors: Keiko Tanaka (Author), Masashi Kitagawa (Author), Akifumi Onishi (Author), Toshio Yamanari (Author), Ayu Ogawa-Akiyama (Author), Koki Mise (Author), Tatsuyuki Inoue (Author), Hiroshi Morinaga (Author), Haruhito A. Uchida (Author), Hitoshi Sugiyama (Author), Jun Wada (Author)
• Format: Book
• Published: Karger Publishers, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1420-4096; 1423-0143; 10.1159/000477453
• Keywords: Brachial-ankle pulse wave velocity; Bleeding; Hemoglobin; Renal biopsy; Dermatology; RL1-803; Diseases of the circulatory (Cardiovascular) system; RC666-701; Diseases of the genitourinary system. Urology; RC870-923
• Source: Kidney & Blood Pressure Research, Vol 42, Iss 2, Pp 284-293 (2017)

Background/Aims: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. Method: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defined as a ≥10% decrease in hemoglobin [Hb] after biopsy). The brachial-ankle pulse wave velocity (baPWV) was measured to evaluate arterial stiffness. Results: This study included 462 patients (male, n=244; female, n=218). Anemia (defined above) was observed in 54 patients (11.7%). The risk of anemia was higher in women, older patients, and patients with lower serum albumin, lower eGFR and lower diastolic blood pressure after biopsy. We then performed a further analysis of 187 patients whose baPWV data were available. Multivariate analysis revealed that a higher baPWV was an independent risk factor for anemia. ROC analysis for predicting anemia found that a baPWV value of 1839 cm/s had the best performance (AUC 0.689). Conclusion: An increased baPWV may be a more valuable predictor of bleeding than any of the other reported risk factors.