Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules

• Main Authors: Andrey D. Bondarev (Author), Misty M. Attwood (Author), Jörgen Jonsson (Author), Vladimir N. Chubarev (Author), Vadim V. Tarasov (Author), Wen Liu (Author), Helgi B. Schiöth (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal transduction system, are long-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a particularly high number of clinical trials involving PDE inhibi...