Cutaneous Involvement in Waldenström's Macroglobulinaemia
Cutaneous involvement in Waldenström's macroglobulinaemia (WM) has been poorly characterized. To describe this involvement, a retrospective study of 19 patients with WM and cutaneous involvement of tumour B cells was performed. Twelve patients (group 1) had lymphoplasmacytic, non-transformed cu...
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Medical Journals Sweden,
2020-08-01T00:00:00Z.
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| 700 | 1 | 0 | |a Anne Durlach |e author |
| 700 | 1 | 0 | |a Marie Beylot-Barry |e author |
| 700 | 1 | 0 | |a Henri Adamski |e author |
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| 700 | 1 | 0 | |a Gérôme Bohelay |e author |
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| 700 | 1 | 0 | |a Olivier Carpentier |e author |
| 700 | 1 | 0 | |a Pascale Cornillet |e author |
| 700 | 1 | 0 | |a Romain Dubois |e author |
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| 700 | 1 | 0 | |a Bérengère Husson |e author |
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| 700 | 1 | 0 | |a Eve Maubec |e author |
| 700 | 1 | 0 | |a Christian le Clech |e author |
| 700 | 1 | 0 | |a Laurent Machet |e author |
| 700 | 1 | 0 | |a Nicolas Ortonne |e author |
| 700 | 1 | 0 | |a Caroline Ram-Wolff |e author |
| 700 | 1 | 0 | |a Béatrice Vergier |e author |
| 700 | 1 | 0 | |a Florent Grange |e author |
| 245 | 0 | 0 | |a Cutaneous Involvement in Waldenström's Macroglobulinaemia |
| 260 | |b Medical Journals Sweden, |c 2020-08-01T00:00:00Z. | ||
| 500 | |a 0001-5555 | ||
| 500 | |a 1651-2057 | ||
| 500 | |a 10.2340/00015555-3535 | ||
| 520 | |a Cutaneous involvement in Waldenström's macroglobulinaemia (WM) has been poorly characterized. To describe this involvement, a retrospective study of 19 patients with WM and cutaneous involvement of tumour B cells was performed. Twelve patients (group 1) had lymphoplasmacytic, non-transformed cutaneous proliferation, while in 7 cases (group 2) cutaneous involvement corresponded to histological transformation. In group 1, skin involvement was inaugural in 6 cases. The lesions were infiltrated plaques (83%), papules (25%) and tumours (42%). Four patients had a similar clinical picture (purplish, bilateral and symmetrical infiltration on the face). MYD88 L265P mutation was detected in the skin biopsy in all 6 cases tested. The 3-year specific survival rate was 88%. In group 2, cutaneous transformation occurred during the follow-up of the WM (71%). Lesions presented as ulcerated tumours (86%) of the trunk (57%) and lower limbs (57%). The 3-year specific survival rate was 22%. Skin involvement in WM has distinctive characteristics (e.g. clinical, histological, immunohistochemical, MYD88 L265P mutation). | ||
| 546 | |a EN | ||
| 690 | |a waldenström's macroglobulinaemia | ||
| 690 | |a cutaneous lymphoma | ||
| 690 | |a diffuse large b-cell lymphoma | ||
| 690 | |a histological transformation | ||
| 690 | |a extranodal involvement | ||
| 690 | |a myd88 l265p mutation | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Dermato-Venereologica, Vol 100, Iss 15, p adv00225 (2020) | |
| 787 | 0 | |n https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3535 | |
| 787 | 0 | |n https://doaj.org/toc/0001-5555 | |
| 787 | 0 | |n https://doaj.org/toc/1651-2057 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a765dabe6abd4f7fa57d9b718bf00e30 |z Connect to this object online. |