Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

• Main Authors: Rhonda M. Brand (Author), Peter Wipf (Author), Austin Durham (Author), Michael W. Epperly (Author), Joel S. Greenberger (Author), Louis D. Falo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Unmitigated UV radiation (UVR) induces skin photoaging and multiple forms of cutaneous carcinoma by complex pathways that include those mediated by UV-induced reactive oxygen species (ROS). Upon UVR exposure, a cascade of events is induced that overwhelms the skin's natural antioxidant defenses...