HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo

• Main Authors: Martin Studenovský (Author), Anna Rumlerová (Author), Jiřina Kovářová (Author), Barbora Dvořáková (Author), Ladislav Sivák (Author), Libor Kostka (Author), Daniel Berdár (Author), Tomáš Etrych (Author), Marek Kovář (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2022-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubility of mebendazole and other benzimidazoles, result...