Interleukin-17 Genes Polymorphisms are Significantly Associated with Cutaneous T-cell Lymphoma Susceptibility
Tumour microenvironment has an important effect on the progression of cutaneous T-cell lymphomas. Using PCR with sequence-specific primers, this study analysed single-nucleotide polymorphisms in the interleukin-17 genes of 150 patients with cutaneous T-cell lymphoma. GG homozygote rs8193036 A/G of i...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Book |
| Published: |
Medical Journals Sweden,
2022-09-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_a7a406586b254bcb81a594f84f29a9b5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Karol Kołkowski |e author |
| 700 | 1 | 0 | |a Jolanta Gleń |e author |
| 700 | 1 | 0 | |a Berenika Olszewska |e author |
| 700 | 1 | 0 | |a Monika Zabłotna |e author |
| 700 | 1 | 0 | |a Roman J. Nowicki |e author |
| 700 | 1 | 0 | |a Małgorzata Sokołowska-Wojdyło |e author |
| 245 | 0 | 0 | |a Interleukin-17 Genes Polymorphisms are Significantly Associated with Cutaneous T-cell Lymphoma Susceptibility |
| 260 | |b Medical Journals Sweden, |c 2022-09-01T00:00:00Z. | ||
| 500 | |a 10.2340/actadv.v102.2416 | ||
| 500 | |a 0001-5555 | ||
| 500 | |a 1651-2057 | ||
| 520 | |a Tumour microenvironment has an important effect on the progression of cutaneous T-cell lymphomas. Using PCR with sequence-specific primers, this study analysed single-nucleotide polymorphisms in the interleukin-17 genes of 150 patients with cutaneous T-cell lymphoma. GG homozygote rs8193036 A/G of interleukin-17A gene occurred less commonly in the cutaneous T-cell lymphoma group; however, patients with this single-nucleotide polymorphism experience significantly intense pruritus. Conversely, the rs2397084 AG heterozygote of interleukin-17F is more common in the lymphoma population. In addition, there were significant differences in the frequencies of interleukin-17 genotypes when comparing early (Ia to IIa) and advanced stages (IIb, III and IV) of this neoplasms. A similar result has been shown in comparison between Sézary syndrome and mycosis fungoides. The current data may serve as a possible explanation for the increased bacterial infection rates in the course of cutaneous T-cell lymphoma, especially caused by Staphylococcus aureus. In summary, specific single-nucleotide polymorphisms occur with different frequencies between cutaneous T-cell lymphoma and healthy patients. Moreover, genetic predisposition of several interleukin-17 single-nucleotide polymorphisms may be a factor causing impaired immune defence in cutaneous lymphomas. | ||
| 546 | |a EN | ||
| 690 | |a cutaneous lymphoma | ||
| 690 | |a mycosis fungoides | ||
| 690 | |a Sézary syndrome | ||
| 690 | |a lymphoma pathogenesis | ||
| 690 | |a single nucleotide polymorphisms | ||
| 690 | |a cytokine | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Dermato-Venereologica, Vol 102 (2022) | |
| 787 | 0 | |n https://medicaljournalssweden.se/actadv/article/view/2416 | |
| 787 | 0 | |n https://doaj.org/toc/0001-5555 | |
| 787 | 0 | |n https://doaj.org/toc/1651-2057 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a7a406586b254bcb81a594f84f29a9b5 |z Connect to this object online. |