Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats

• Main Authors: Mengjia Li (Author), Zhengbo Wang (Author), Tianqi Zheng (Author), Tianzhuang Huang (Author), Baoguo Liu (Author), Deqiang Han (Author), Sumei Liu (Author), Bochao Liu (Author), Mo Li (Author), Wei Si (Author), Y. Alex Zhang (Author), Yuyu Niu (Author), Zhiguo Chen (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neural stem cells (NSCs) and derivatives are potential cellular sources to treat neurological diseases. In the current study, we reprogrammed human peripheral blood mononuclear cells into induced NSCs (iNSCs) and inserted GFP gene into the AAVS1 site for graft tracing. Targeted integration of GFP do...