Autworks: a cross-disease network biology application for Autism and related disorders
<p>Abstract</p> <p>Background</p> <p>The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology...
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| Main Authors: | , , , , , |
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| Format: | Book |
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BMC,
2012-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Abstract</p> <p>Background</p> <p>The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results.</p> <p>Description</p> <p>We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis.</p> <p>Conclusions</p> <p>Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders.</p> <p>Availability: <url>http://autworks.hms.harvard.edu/</url></p> |
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| Item Description: | 10.1186/1755-8794-5-56 1755-8794 |