Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents
Purpose: In this study, a series of piperazin-2-one derivatives were prepared through bioisosteric substitution of the imidazole ring of L-778,123 (imidazole-containing FTase inhibitor) and rearrangement of groups based on the tipifarnib structure. Final compounds were evaluated for their cytotoxic...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Tabriz University of Medical Sciences,
2020-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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