Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury

Traumatic brain injury (TBI) is a major global health problem that affects both civilian and military populations worldwide. Post-injury acute, sub-acute, and chronic progression of secondary injury processes may contribute further to other neurodegenerative diseases. However, there are no approved...

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Main Authors: Hiren R. Modi (Author), Sudeep Musyaju (Author), Meaghan Ratcliffe (Author), Deborah A. Shear (Author), Anke H. Scultetus (Author), Jignesh D. Pandya (Author)
Format: Book
Published: MDPI AG, 2024-02-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Hiren R. Modi  |e author 
700 1 0 |a Sudeep Musyaju  |e author 
700 1 0 |a Meaghan Ratcliffe  |e author 
700 1 0 |a Deborah A. Shear  |e author 
700 1 0 |a Anke H. Scultetus  |e author 
700 1 0 |a Jignesh D. Pandya  |e author 
245 0 0 |a Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury 
260 |b MDPI AG,   |c 2024-02-01T00:00:00Z. 
500 |a 10.3390/antiox13030303 
500 |a 2076-3921 
520 |a Traumatic brain injury (TBI) is a major global health problem that affects both civilian and military populations worldwide. Post-injury acute, sub-acute, and chronic progression of secondary injury processes may contribute further to other neurodegenerative diseases. However, there are no approved therapeutic options available that can attenuate TBI-related progressive pathophysiology. Recent advances in preclinical research have identified that mitochondria-centric redox imbalance, bioenergetics failure and calcium dysregulation play a crucial role in secondary injury progression after TBI. Mitochondrial antioxidants play an important role in regulating redox homeostasis. Based on the proven efficacy of preclinical and clinical compounds and targeting numerous pathways to trigger innate antioxidant defense, we may be able to alleviate TBI pathology progression by primarily focusing on preserving post-injury mitochondrial and cerebral function. In this review, we will discuss novel mitochondria-targeted antioxidant compounds, which offer a high capability of successful clinical translation for TBI management in the near future. 
546 |a EN 
690 |a traumatic brain injury 
690 |a mitochondria 
690 |a free radicals 
690 |a oxidative stress 
690 |a cell death 
690 |a antioxidants 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 13, Iss 3, p 303 (2024) 
787 0 |n https://www.mdpi.com/2076-3921/13/3/303 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/a842b4e7f3e1492785c05e8b77a3e358  |z Connect to this object online.