Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries

• Format: Book
• Published: Hindawi Limited, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p><emph>Aims.</emph> Our aim is to investigate, in <mml:math> <mml:mn>13</mml:mn> </mml:math> cases (delivering preterm) and <mml:math> <mml:mn>21</mml:mn> </mml:math> matched (for age, parity, and gestational age) controls (delivering at term), whether midtrimester amniotic fluid concentrations of elastase, secretory leukocyte proteinase inhibitor (SLPI), soluble intercellular adhesion molecule-<mml:math> <mml:mn>1</mml:mn> </mml:math>, and soluble vascular cell adhesion molecule predict asymptomatic intra-amniotic inflammation/infection and preterm labor. <emph> Results.</emph> Concentrations of all substances were not statistically different among mothers, delivering preterm or at term. SLPI concentrations significantly increased in women, going into labor without ruptured membranes, irrespective of pre- or term delivery (<mml:math> <mml:mi>p</mml:mi><mml:mo>&#x003C;</mml:mo><mml:mn>.007</mml:mn> </mml:math>, <mml:math> <mml:mi>p</mml:mi><mml:mo>&#x003C;</mml:mo><mml:mn>.001</mml:mn> </mml:math>, resp) and correlated with elastase (<mml:math> <mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.508</mml:mn> </mml:math>, <mml:math> <mml:mi>p</mml:mi><mml:mo>&#x003C;</mml:mo><mml:mn>.002</mml:mn> </mml:math>). <emph>Conclusions.</emph> Midtrimester amniotic fluid SLPI concentrations significantly decrease when membrane rupture precedes pre- or full-term labor. However, none of the investigated substances predict preterm delivery.</p>

Item Description

0962-9351