Drug repurposing against coronavirus disease 2019 (COVID-19): A review

Since December 2019, severe acute respiratory syndrome coronavirus 2 has been found to be the culprit in the coronavirus disease 2019 (COVID-19), causing a global pandemic. Despite the existence of many vaccine programs, the number of confirmed cases and fatalities due to COVID-19 is still increasin...

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Main Authors: Lianxiang Luo (Author), Qin Qiu (Author), Fangfang Huang (Author), Kaifeng Liu (Author), Yongqi Lan (Author), Xiaoling Li (Author), Yuge Huang (Author), Liao Cui (Author), Hui Luo (Author)
Format: Book
Published: Elsevier, 2021-12-01T00:00:00Z.
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Summary:Since December 2019, severe acute respiratory syndrome coronavirus 2 has been found to be the culprit in the coronavirus disease 2019 (COVID-19), causing a global pandemic. Despite the existence of many vaccine programs, the number of confirmed cases and fatalities due to COVID-19 is still increasing. Furthermore, a number of variants have been reported. Because of the absence of approved anti-coronavirus drugs, the treatment and management of COVID-19 has become a global challenge. Under these circumstances, drug repurposing is an effective method to identify candidate drugs with a shorter cycle of clinical trials. Here, we summarize the current status of the application of drug repurposing in COVID-19, including drug repurposing based on virtual computer screening, network pharmacology, and bioactivity, which may be a beneficial COVID-19 treatment.
Item Description:2095-1779
10.1016/j.jpha.2021.09.001