Formulation, Stability and Bioequivalency Study of Prepared Salbutamol Sulphate Nebules.
Salbutamol sulphate nebules is considered as the most rapid effective route of administration for treatment of acute attacks of asthma . This study was carried out to formulate a stable formula of salbutamol nebules containing 0.1% (2.5mg / 2.5ml) of the active ingredient in a buffered solution . St...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Published: |
College of Pharmacy University of Baghdad,
2017-03-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_a8927e49cd0e4ed89095572c58a22d5f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Bazigha K. Al â€"Temimy |e author |
| 700 | 1 | 0 | |a Alaa A. Abdul â€"Rasool |e author |
| 245 | 0 | 0 | |a Formulation, Stability and Bioequivalency Study of Prepared Salbutamol Sulphate Nebules. |
| 260 | |b College of Pharmacy University of Baghdad, |c 2017-03-01T00:00:00Z. | ||
| 500 | |a 10.31351/vol14iss1pp65-74 | ||
| 500 | |a 2521-3512 | ||
| 500 | |a 1683-3597 | ||
| 520 | |a Salbutamol sulphate nebules is considered as the most rapid effective route of administration for treatment of acute attacks of asthma . This study was carried out to formulate a stable formula of salbutamol nebules containing 0.1% (2.5mg / 2.5ml) of the active ingredient in a buffered solution . Stability study in different buffers at pH 3 showed that the longest shelf life was equal to 3.5 years for formula F .In addition the bioequivalency of this formula incomparison to ventolin® nebules was measured and it was equal to (± 5.2) %. Also it was found that there was no significant difference between the formula and ventolin® nebules regarding their pharmacokinetic parameters which include elimination rate constant, elimination t 0.5 and amount of the unchanged drug excreted in urine, 30 min. after administration (p<0.05) . This study may suggest that the prepared formula could be used successfully in the preparation of salbutamol sulphate nebules. | ||
| 546 | |a EN | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Iraqi Journal of Pharmaceutical Sciences, Vol 14, Iss 1 (2017) | |
| 787 | 0 | |n https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/614 | |
| 787 | 0 | |n https://doaj.org/toc/2521-3512 | |
| 787 | 0 | |n https://doaj.org/toc/1683-3597 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a8927e49cd0e4ed89095572c58a22d5f |z Connect to this object online. |