Novel glyproline GZK-111 with neuropsychotropic activity
Thе article represents a review of our own researches, which describes the design, synthesis and pharmacological properties of linear substituted glyproline GZK-111, a potential drug for the complex treatment of psychiatric pathologies, including anxiety, depressive disorders, and cognitive impairme...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
LLC "Publisher OKI",
2022-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Thе article represents a review of our own researches, which describes the design, synthesis and pharmacological properties of linear substituted glyproline GZK-111, a potential drug for the complex treatment of psychiatric pathologies, including anxiety, depressive disorders, and cognitive impairment. The relationship between structure and activity in a series of this glyproline analogs is described. The experimental evidence of the GZK-111 ability to metabolized with the formation of cycloprolylglycine, which is identical to the endogenous cyclic dipeptide, is presented. The data on toxicological and pharmacokinetic studies of GZK-111 are presented. |
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| Item Description: | 2587-7836 2686-8830 10.37489/2587-7836-2021-4-18-23 |