Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes

• Main Authors: Victoriane Peugnet (Author), Maggy Chwastyniak (Author), Paul Mulder (Author), Steve Lancel (Author), Laurent Bultot (Author), Natacha Fourny (Author), Edith Renguet (Author), Heiko Bugger (Author), Olivia Beseme (Author), Anne Loyens (Author), Wilfried Heyse (Author), Vincent Richard (Author), Philippe Amouyel (Author), Luc Bertrand (Author), Florence Pinet (Author), Emilie Dubois-Deruy (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heart failure, mostly associated with cardiac hypertrophy, is a major cause of illness and death. Oxidative stress causes accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction, suggesting that mitochondria-targeted therapies could be effective in this context. The purpo...