Immunology Team-Based Learning: Receptor Diversity & Antigen Presentation

• Main Authors: Wayne McCormack (Author), David Ostrov (Author)
• Format: Book
• Published: Association of American Medical Colleges, 2009-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.15766/mep_2374-8265.7729; 2374-8265
• Keywords: TBL; Team-Based Learning; Major Histocompatibility Complex; Antigen Presentation; T Cell Receptors; Immunoglobulin; Medicine (General); R5-920; Education; L
• Source: MedEdPORTAL, Vol 5 (2009)

Abstract Introduction This module is one of three developed for second-year biomedical science MS and PhD students enrolled in a semester-long immunology graduate course titled Principles in Immunology. This material is also appropriate for basic science courses for medical and dental students and/or for review of immunology by residents and fellows. Topics covered by the remaining modules include basic concepts of immunology and innate immunity and recognition of antigen. Methods This module uses a team-based learning format (TBL) to help learners understand the following immunological principles and how to apply them in experimental settings: the molecular mechanisms by which diverse antigen receptors are created in developing B- and T-lymphocytes, differences between immunoglobulin and T-cell receptor (TCR) structure and function, the genomic organization of immunoglobulin, TCR and major histocompatibility complex (MHC) genes, and pathways by antigen presenting cells process and present antigenic peptides via MHC molecules. Students arrive to class having read preassigned readings. They then complete an individual readiness assurance test, before completing the same test in groups. Students then remain in these groups while they complete a series of group application exercises. Results Student satisfaction with TBL is very high as assessed by course evaluations over the past 3 years. Students say that TBL helps them keep up with material and helps them prepare for exams. Student performance on high-stakes exams reveals modest improvements in overall scores (manuscript in preparation). Student performance in a graduate level immunology course did not drop after implementation of TBL, which involved replacing nine of 42 lectures throughout the semester with TBL sessions. Graduate students enjoy TBL and learning appears to be enhanced. Discussion Originally developed for second-year biomedical science MS and PhD students enrolled in a semester-long immunology graduate course, this material is also appropriate for basic science courses for medical and dental students and/or for review of immunology by residents and fellows.