Identification and Development of BRD9 Chemical Probes

• Ngā kaituhi matua: Ester Colarusso (Author), Maria Giovanna Chini (Author), Giuseppe Bifulco (Author), Gianluigi Lauro (Author), Assunta Giordano (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2024-03-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The development of BRD9 inhibitors involves the design and synthesis of molecules that can specifically bind the BRD9 protein, interfering with the function of the chromatin-remodeling complex ncBAF, with the main advantage of modulating gene expression and controlling cellular processes. Here, we s...