Cover Image

Trouble shooting during bioanalytical estimation of drug and metabolites using LC-MS/MS: A review

Show other versions (1)

Bioanalysis frequently involves the measurement of very low analyte concentrations in complex and potentially variable matrices. An initial attempt has been made to apply a risk management tool to the bioanalytical method development like selection of spiked plasma volume, selection of internal stan...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ganesh N Sharma (Author), Man Mohan Singhal (Author), K K Sharma (Author), Jyotsana Sanadya (Author)
Format:	Book
Published:	Wolters Kluwer Medknow Publications, 2010-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

TROUBLE SHOOTING DURING BIOANALYTICAL ESTIMATION OF DRUG AND METABOLITES USING LC-MS/MS: A REVIEW
by: K.K.Sharma, et al.
Published: (2010)

Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies
by: Bhupinder Singh, et al.
Published: (2013)

Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS
by: Pridhvi Krishna Gaddey, et al.
Published: (2024)

Development and validation of bexarote by bioanalytical methods using liquid chromatography-tandem mass spectroscopy (LC-MS/MS)
by: K. Nagaraju, et al.
Published: (2021)

An LC-MS/MS Bioanalytical Assay for the Determination of Gilteritinib in Rat Plasma and Application to a Drug–Drug Interaction Study
by: Wang Q, et al.
Published: (2020)

A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS
by: Srikanth Inturi, et al.
Published: (2018)

A Comprehensive Immunocapture-LC-MS/MS Bioanalytical Approach in Support of a Biotherapeutic Ocular PK Study
by: Lin-Zhi Chen, et al.
Published: (2024)

Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS
by: Nirav P. Patel, et al.
Published: (2018)

Highly sensitive LC-MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study
by: Nirav P. Patel, et al.
Published: (2018)

LC-MS/MS Estimation of Propranolol level in Exhaled Breath Condensate
by: Samin Hamidi 1, Maryam Amini 2, Maryam Khoubnasabjafari 3, Vahid Jouyban-Gharamaleki 4,5, Hossein Sate 6, Abolghasem Jouyban 5,7 *
Published: (2017)

Metabolic Stability and Metabolite Characterization of Capilliposide B and Capilliposide C by LC-QTRAP-MS/MS
by: Zhongzhe Cheng, et al.
Published: (2018)

Profiling Analysis of Tryptophan Metabolites in the Urine of Patients with Parkinson's Disease Using LC-MS/MS
by: So Hyeon Chung, et al.
Published: (2023)

An LC-MS/MS Method for Quantification of Lamotrigine and Its Main Metabolite in Dried Blood Spots
by: Daniela Milosheska, et al.
Published: (2024)

Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients
by: Hannah Kipka, et al.
Published: (2022)

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation
by: Attwa MW, et al.
Published: (2021)

Simultaneous determination of candesartan and hydrochlorothiazide in human plasma by LC-MS/MS
by: Mohan Gandhi Bonthu, et al.
Published: (2018)

LC-MS/MS Method for Mycotoxin Analysis
by: Aldo Laganà (Ed.)
Published: (2017)

Application of LC-MS/MS in the Mycotoxins Studies
Published: (2020)

Bioanalytical method development and validation for the simultaneous estimation of Olanzapine and Samidorphan in rabbit plasma by using HPLC-MS/MS and application to pharmacokinetic study
by: Rambabu Kantipudi, et al.
Published: (2024)

Structural Elucidation of Novel Stable and Reactive Metabolites of Green Tea Catechins and Alkyl Gallates by LC-MS/MS
by: Ons Ousji, et al.
Published: (2022)

LC and LC-MS/MS studies for the identification and characterization of degradation products of acebutolol
by: Uday Rakibe, et al.
Published: (2018)

Development and validation of an LC-MS/MS method for tyrphostin A9
by: Lyndsey F. Meyer, et al.
Published: (2019)

Method development and validation of cabozantinib by LC-MS/MS
by: Punna Venkateshwarlu, et al.
Published: (2022)

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach
by: Abdelhameed AS, et al.
Published: (2020)

Determination of Phthalate Metabolites in Human Serum and Urine as Biomarkers for Phthalate Exposure Using Column-Switching LC-MS/MS
by: Jee Yeon Jeong, et al.
Published: (2011)

Metabolite Profiling of Methanolic Extract of <i>Gardenia jaminoides</i> by LC-MS/MS and GC-MS and Its Anti-Diabetic, and Anti-Oxidant Activities
by: Kandasamy Saravanakumar, et al.
Published: (2021)

Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy
by: Fulin Jiang, et al.
Published: (2024)

Secondary metabolite profiling and characterization of diterpenes and flavones from the methanolic extract of Andrographis paniculata using HPLC-LC-MS/MS
by: Manish Kumar Dwivedi, et al.
Published: (2021)

LC-MS/MS assay for olanzapine in human plasma and its application to a bioequivalence study
by: Dinesh S. Patel, et al.
Published: (2012)

LC-MS study analyzing tongue coating metabolites in intra-oral halitosis patients
by: Dr Wenjie Yang
Published: (2023)

Clinical Significance of Screening Differential Metabolites in Ovarian Cancer Tissue and Ascites by LC/MS
by: Miao Liu, et al.
Published: (2021)

Cannabidiol, ∆9-tetrahydrocannabinol, and metabolites in human blood by volumetric absorptive microsampling and LC-MS/MS following controlled administration in epilepsy patients
by: Federica Pigliasco, et al.
Published: (2022)

Strategies for Developing Sensitive and Automated LC-MS/MS Assays of a Pharmaceutical Compound and Its Metabolite from Whole Blood Matrix
by: Raymond N. Xu, et al.
Published: (2010)

Short-cut route validated for monitoring fentanyl and its metabolite in urine using LC-MS/MS, in a wide concentration range
by: Fatma Cavus Yonar, et al.
Published: (2024)

New analytical LC-MS/MS method for fluconazole and ivermectin estimation in combined pharmaceutical dosage form: development and validation
by: Popat Mohite, et al.
Published: (2023)

Dexamethasone and diclofenac confirmation by LC-MS-MS as herbal product adulterants
by: Lourdes Garza-Ocañas, et al.
Published: (2013)

Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS
by: Robert Skibiński, et al.
Published: (2018)

Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC-MS/MS
by: Chengyin Zhang, et al.
Published: (2018)

Rapid LC-MS/MS method for determination of scopolamine in human plasma
by: Anas Alshishani, et al.
Published: (2022)

<i>Fragaria viridis</i> Fruit Metabolites: Variation of LC-MS Profile and Antioxidant Potential during Ripening and Storage
by: Daniil N. Olennikov, et al.
Published: (2020)