Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design
The objective of this work was to apply central composite experimental design to investigate main and interaction effect of formulation parameters in optimizing novel fast disintegration tablets formulation using pullulan as diluents. Face centered central composite experimental design was employed...
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2012-01-01T00:00:00Z.
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| 001 | doaj_a989c26a3a094efb8f80c46ed4c0a63c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Dipil Patel |e author |
| 700 | 1 | 0 | |a Musharraf Chauhan |e author |
| 700 | 1 | 0 | |a Ravi Patel |e author |
| 700 | 1 | 0 | |a Jayvadan Patel |e author |
| 245 | 0 | 0 | |a Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design |
| 260 | |b Wolters Kluwer Medknow Publications, |c 2012-01-01T00:00:00Z. | ||
| 500 | |a 0975-7406 | ||
| 500 | |a 0976-4879 | ||
| 500 | |a 10.4103/0975-7406.94150 | ||
| 520 | |a The objective of this work was to apply central composite experimental design to investigate main and interaction effect of formulation parameters in optimizing novel fast disintegration tablets formulation using pullulan as diluents. Face centered central composite experimental design was employed to optimize fast disintegration tablet formulation. The variables studied were concentration of diluents (pullulan, X1), superdisintigrant (sodium starch glycolate, X2), and direct compression aid (spray dried lactose, X3). Tablets were characterized for weight variation, thickness, disintegration time (Y1) and hardness (Y2). Good correlation between the predicted values and experimental data of the optimized formulation methodology in optimizing fast disintegrating tablets using pullulan as a diluent. | ||
| 546 | |a EN | ||
| 690 | |a Pullulan | ||
| 690 | |a central composite experimental design | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 690 | |a Analytical chemistry | ||
| 690 | |a QD71-142 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacy and Bioallied Sciences, Vol 4, Iss 5, Pp 86-87 (2012) | |
| 787 | 0 | |n http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=86;epage=87;aulast=Patel | |
| 787 | 0 | |n https://doaj.org/toc/0975-7406 | |
| 787 | 0 | |n https://doaj.org/toc/0976-4879 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a989c26a3a094efb8f80c46ed4c0a63c |z Connect to this object online. |