Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity

• Main Authors: Eunice E. To (Author), Jonathan R. Erlich (Author), Felicia Liong (Author), Stella Liong (Author), Raymond Luong (Author), Osezua Oseghale (Author), Mark A. Miles (Author), Paris C. Papagianis (Author), Kylie M. Quinn (Author), Steven Bozinovski (Author), Ross Vlahos (Author), Robert D. Brooks (Author), John J. O'Leary (Author), Doug A. Brooks (Author), Stavros Selemidis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an urgent need to develop effective therapeutic strategies including immunomodulators to combat influenza A virus (IAV) infection. Influenza A viruses increase ROS production, which suppress anti-viral responses and contribute to pathological inflammation and morbidity. Two major cellular s...