Cover Image

Bioavailability of everolimus administered as a single 5 mg tablet versus five 1 mg tablets: a randomized, open-label, two-way crossover study of healthy volunteers

Karen Thudium,1 Jorge Gallo,2 Emmanuel Bouillaud,2 Carolin Sachs,2 Simantini Eddy,1 Wing Cheung1 1Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 2Novartis Pharma AG, Basel, Switzerland Background: The mammalian target of rapamycin (mTOR) inhibitor everolimus has a well-established phar...

Full description

Saved in:

Bibliographic Details
Main Authors:	Thudium K (Author), Gallo J (Author), Bouillaud E (Author), Sachs C (Author), Eddy S (Author), Cheung W (Author)
Format:	Book
Published:	Dove Medical Press, 2015-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Bioequivalence of generic alendronate sodium tablets (70 mg) to Fosamax® tablets (70 mg) in fasting, healthy volunteers: a randomized, open-label, three-way, reference-replicated crossover study
by: Zhang Y, et al.
Published: (2017)

Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers
by: Vishal Goyal, et al.
Published: (2024)

Study of the effect of food on the bioavailability, safety and tolerability of Aterixen<sup>®</sup> 100 mg tablet in healthy volunteers
by: V. B. Vasilyuk, et al.
Published: (2023)

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers
by: Radicioni M, et al.
Published: (2017)

Bioequivalence Study of 100-mg Cilostazol Tablets in Healthy Thai Adult Volunteers
by: Somruedee Chatsiricharoenkul, MD, et al.
Published: (2019)

Bioequivalence and Safety of Bilastine 20 mg Orodispersible Tablets and Conventional Tablets: A Randomized, Single-Dose, Two-Period Crossover Study in Healthy Volunteers Under Fasting Conditions
by: Manuel Román, et al.
Published: (2024)

A Randomized, Two-Treatments, Two-Periods, Crossover, Open label, Laboratory-Blind, Single Dose Bioequivalence Study between Vildagliptin/Metformin 50 mg/1000 mg Film Coated Tablets (Sensityn®) and Galvusmet® 50 mg/1000 mg Film Coated Tablets in healthy adults under fed conditions
by: Shiekmydeen J., et al.
Published: (2023)

Evaluation of the bioequivalence of two formulations containing the combination of 400 mg of acetaminophen (paracetamol), 4 mg of phenylephrine and 4 mg of chlorpheniramine in capsules: open-label, three-way crossover study, partially replicated in healthy volunteers of both sexes
by: Alessandra Ferreira dos Santos, et al.
Published: (2020)

A Phase 1, randomized, open-label crossover study to evaluate the safety and pharmacokinetics of 400 mg albaconazole administered to healthy participants as a tablet formulation versus a capsule formulation
by: van Rossem K, et al.
Published: (2013)

Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers.
by: Jose Muñoz, et al.
Published: (2018)

Bioequivalence study of abacavir/lamivudine (600/300-mg) tablets in healthy Thai volunteers under fasting conditions
by: Ekawan Yoosakul, et al.
Published: (2016)

The effect of some excipients on the formulation of norfloxacin 400mg tablets
by: Al-Khalidi S. Siham
Published: (2004)

Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions
by: Wu L, et al.
Published: (2019)

A comparative study of pharmacokinetics and bioequivalence of Cardiopril tablets 20 mg (JSC «Himfarm», Kazakhstan) and Monopril® tablets of 20 mg («Bristol-Myers Squibb SRL», Italy)
by: A. K. Sariev, et al.
Published: (2014)

Relative bioavailability of a pediatric dispersible tablet and adult film‐coated tablet of macitentan in healthy volunteers
by: Patricia N. Sidharta, et al.
Published: (2020)

Bioequivalence studies Nipezam retard tablets, 400 mg (JSC «Himfarm», Kazakhstan) and Finlepsin® 400 retard tablets 400 mg («Pliva Krakow, SA Pharmaceutical company», Poland)
by: A. K. Sariev, et al.
Published: (2014)

Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets
by: Hwang JG, et al.
Published: (2020)

Comparative bioequivalence study of Pioglitazone tablets, 20 mg (JSC «Chimpharm», Kazakhstan) and Actos® Tablets, 30 mg («Eli Lilly Holdings, Takeda Global Research and Development Centre Europe Ltd»)
by: A. K. Sariev, et al.
Published: (2013)

Comparative bioequivalence studies of tramadol hydrochloride sustained-release 200 mg tablets
by: Suhas S Khandave, et al.
Published: (2010)

Effect of binders on 500mg metformin hydrochloride tablets produced by wet granulation
by: L.C. Block, et al.
Published: (2009)

Enteric coating of ibuprofen tablets (200 mg) using an aqueous dispersion system
by: Rabia Bushra, et al.
Published: (2010)

Bioequivalence of bisoprolol, coated tablets 10 mg JSC «Chimpharm» Republic of Kazakhstan
by: Y. M. Budach, et al.
Published: (2013)

Dissolution kinetics of propranolol hydrochloride 40 mg tablets under biowaiver conditions
by: Lennin R. Rodriguez-Saavedra, et al.
Published: (2024)

Cost-effectiveness of weekly gastro-resistant risedronate 35 mg, compared with weekly alendronate 70 mg tablets, in the treatment of postmenopausal osteoporosis in Spain
by: Enrique Casado, et al.
Published: (2023)

Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure
by: Ballester MR, et al.
Published: (2015)

Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension
by: Yagi S, et al.
Published: (2015)

Development of Gastroretentive Floating Combination Tablets Containing Amoxicillin Trihydrate 500 mg and Levofloxacin 125 mg for Eradicating Resistant <i>Helicobacter pylori</i>
by: Da Hun Kim, et al.
Published: (2024)

Average bioequivalence of single 500 mg doses of two oral formulations of levofloxacin: a randomized, open-label, two-period crossover study in healthy adult Brazilian volunteers
by: Eunice Kazue Kano, et al.
Published: (2015)

Suvorexant (Belsomra® Tablets 10, 15, and 20 mg): Japanese Drug-Use Results Survey
by: Yuko Asai, et al.
Published: (2018)

Study of the pharmacokinetic profile of the medicinal product Gidazepam®, tablets, 50 mg in a bioequivalence study
by: E. V. Baskakov, et al.
Published: (2023)

<b>Effect of binders on 500mg metformin hydrochloride tablets produced by wet granulation</b>
by: LUCIANA CATIA BLOCK, et al.
Published: (2009)

In vitro bioequivalence profile of Penicillin V tablets marketed in Kisangani, Democratic Republic of the Congo: Assay and dissolution kinetics of generic 250 mg and originator 600 mg
by: Rachel Ndezu Angirio, et al.
Published: (2024)

Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adults: An Open-Label, Randomized, Single-Dose, Crossover, Relative Bioavailability Study
by: Spencer C. Greene, MD, FACEP, FACMT, et al.
Published: (2016)

Bioequivalence study of low dose drospirenone/ethinyl estradiol 3 mg/0.03 mg film tablets under fasting conditions in Turkish healthy female subjects
by: Ahmet Inal, et al.
Published: (2024)

Pharmacokinetics and Bioavailability Study of a Prednisolone Tablet as a Single Oral Dose in Bangladeshi Healthy Volunteers
by: Tafsir Bashar MPharm, et al.
Published: (2018)

Pharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers
by: Huang J, et al.
Published: (2018)

Bioavailability of Epigallocatechin Gallate Administered with Different Nutritional Strategies in Healthy Volunteers
by: Vicente Andreu Fernández, et al.
Published: (2020)

Preparation and release study of Levetiracetam 500 mg extended release tablet by using combination of hydrophilic and hydrophobic polymers.
by: Mohamad Reza Avadi, et al.
Published: (2018)

Pharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study
by: Yang E, et al.
Published: (2021)

Bioavailability of norfloxacin tablets commercially available in Thailand
by: Anong Teachanukulchai
Published: (2013)