EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA

• Main Authors: I. G. Fomina (Author), G. K. Makchnach (Author), D. A. Zateyschikova (Author), A. I. Tarzimanova (Author)
• Format: Book
• Published: Столичная издательская компания, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p><strong>Aim.</strong> To study effects of sympathomimetic agents on electrocardiogram (ECG) indexes in patients with bronchial asthma (BA) in exacerbation stage complicated by respiratory insufficiency and sympathomimetic agents overdose.</p><p><strong>Material and methods.</strong> 40 patients with persistent BA of various severities with respiratory insufficiency and sympathomimetic agents overdose were investigated. ECG was performed and P wave, QRS, duration and dispersion of corrected QT interval (QTc) were analyzed.</p><p><strong>Results.</strong> Mean QTc dispersion correlated with asthma severity and was 76,8±5,9 ms1/2, 87,9±5,1 ms1/2, 87,8±3,1 ms1/2 in patients with mild, moderate and severe BA, respectively. Significant correlation between QTc dispersion and BA duration was found. QTc dispersion level was directly connected with duration of use of β-agonists and their overdose. Average QTc dispersion in patients who used more than 20 daily doses of inhaled β-agonists was 89,0±5,8 ms1/2.</p><p><strong>Conclusion.</strong> Increase in QTc dispersion directly depends on BA duration and severity. β-agonist overdose results in growth of QTc dispersion, which has arrhythmogenic potential.</p>

Item Description

1819-6446
2225-3653
10.1234/1819-6446-2007-1-15-20