Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge

• Main Authors: Ramin Tolouian (Author), Audrey Tolouian (Author), Farzaneh Dastan (Author), Vida Farhangi (Author), Payam Peymani (Author), Sanam Saeifar (Author), Oscar Felipe Borja Montes (Author), Leila Mohmoodnia (Author), Mohammadreza Khosravifarsani (Author), Tella Sadighpour (Author)
• Format: Book
• Published: Society of Diabetic Nephropathy Prevention, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Cisplatin is a first-line antitumor drug which is applied in the therapeutic field of numerous kinds of cancers. The main dose-dependent adverse effect of cisplatin is nephrotoxicity in approximately one-third of patients, who received this drug during their treatment. Oxidative stress is one of the most significant mechanisms in cisplatin nephrotoxicity. Cisplatin-induced oxidative stress stimulates apoptosis, inflammation, mitochondrial damage within cells, and endoplasmic reticulum (ER) stress. The administration of an antioxidant in this context could be a suitable approach for preventing of cisplatin nephrotoxicity. Antioxidants are categorized into four classes: dietary antioxidants, free radical scavengers, thiol-containing compounds, and iron chelators.

Item Description

2345-4202
10.34172/npj.2022.10556