Low-Dose Interleukin-2 Altered Gut Microbiota and Ameliorated Collagen-Induced Arthritis
Na Li,1 Xuefei Li,1 Rui Su,1 Ruihe Wu,1 Hong-Qing Niu,1 Jing Luo,1 Chong Gao,2 Xiaofeng Li,1 Caihong Wang1 1Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China; 2Pathology, Joint Program in Transfusion Medicine, Brigham and W...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Dove Medical Press,
2022-02-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_a9c5cee94e924ef8b23457dfcb798f60 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Li N |e author |
| 700 | 1 | 0 | |a Li X |e author |
| 700 | 1 | 0 | |a Su R |e author |
| 700 | 1 | 0 | |a Wu R |e author |
| 700 | 1 | 0 | |a Niu HQ |e author |
| 700 | 1 | 0 | |a Luo J |e author |
| 700 | 1 | 0 | |a Gao C |e author |
| 700 | 1 | 0 | |a Li X |e author |
| 700 | 1 | 0 | |a Wang C |e author |
| 245 | 0 | 0 | |a Low-Dose Interleukin-2 Altered Gut Microbiota and Ameliorated Collagen-Induced Arthritis |
| 260 | |b Dove Medical Press, |c 2022-02-01T00:00:00Z. | ||
| 500 | |a 1178-7031 | ||
| 520 | |a Na Li,1 Xuefei Li,1 Rui Su,1 Ruihe Wu,1 Hong-Qing Niu,1 Jing Luo,1 Chong Gao,2 Xiaofeng Li,1 Caihong Wang1 1Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China; 2Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital/Children's Hospital, Harvard Medical School, Boston, MA, USACorrespondence: Caihong Wang, Tel +8613603515399, Fax +863513365551, Email snwch@sina.comPurpose: Low-dose interleukin-2 (ld-IL-2) has been shown to regulate the balance between effector T and regulatory T (Treg) cells and has been used in several clinical trials to treat autoimmune diseases including rheumatoid arthritis (RA). In this study, we investigated the effects of ld-IL-2 on collagen-induced arthritis (CIA) in mice.Methods: Arthritis severity in CIA mice was measured using the arthritis index (AI), radiographs, and hematoxylin and eosin staining. Cytokines were detected using enzyme-linked immunosorbent assay. Gut microbiota alterations and short-chain fatty acid production were analyzed through 16S rRNA sequencing and gas chromatography.Results: The AI scores of CIA mice treated with ld-IL-2 were significantly lower compared to the model group, which significantly reduced the severity of arthritis. Ld-IL-2 also altered the gut microbiota in CIA mice. The diversity, composition, and dominant species of gut microbiota were altered by ld-IL-2 treatment. Ld-IL-2 also increased short-chain fatty acid levels. There was a strong correlation between ld-IL-2 treatment and improved gut microbiota.Conclusion: Ld-IL-2 significantly ameliorated joint inflammation and bone damage and improved gut microbial dysbiosis in CIA, indicating that it may be a promising therapy for RA patients.Keywords: low-dose IL-2, CIA, gut microbiota, SCFA, 16sRNA | ||
| 546 | |a EN | ||
| 690 | |a low-dose il-2 | ||
| 690 | |a cia | ||
| 690 | |a gut microbiota | ||
| 690 | |a scfa | ||
| 690 | |a 16srna | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Inflammation Research, Vol Volume 15, Pp 1365-1379 (2022) | |
| 787 | 0 | |n https://www.dovepress.com/low-dose-interleukin-2-altered-gut-microbiota-and-ameliorated-collagen-peer-reviewed-fulltext-article-JIR | |
| 787 | 0 | |n https://doaj.org/toc/1178-7031 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a9c5cee94e924ef8b23457dfcb798f60 |z Connect to this object online. |