Promising inhibition of diabetes-related enzymes and antioxidant properties of Ptilostemon casabonae leaves extract

• Main Authors: Cinzia Sanna (Author), Antonella Fais (Author), Benedetta Era (Author), Giovanna L. Delogu (Author), Enrico Sanna (Author), Laura Dazzi (Author), Antonella Rosa (Author), Arianna Marengo (Author), Patrizia Rubiolo (Author), Antonio De Agostini (Author), Sonia Floris (Author), Francesca Pintus (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Type 2 diabetes (T2D) is a progressive metabolic disorder of glucose metabolism. One of the therapeutic approaches for the treatment of T2D is reducing postprandial hyperglycaemia through inhibition of the digestive enzymes α-glucosidase and α-amylase. In this context, aimed at identifying natural products endowed with anti-T2D potential, we focused on Ptilostemon casabonae (L.) Greuter, a species belonging to Asteraceae family. Enzymatic inhibition, antioxidant activity, phenolic composition and cellular assays were performed. This study revealed that the P. casabonae hydroalcoholic extract exerts a potent inhibitory activity against α-glucosidase. This activity is supported by an antioxidant effect, preventing ROS formation in a stressed cellular system. HPLC-PDA-MS/MS analysis, revealed a complex polyphenolic fraction. Among the tested pure compounds, 1,5-dicaffeoylquinic acid, apigenin and rutin displayed good α-glucosidase inhibitory activity. Our study suggested new potential of P. casabonae encouraging us to further testing the possible therapeutic potential of this extract.

Item Description

10.1080/14756366.2023.2274798
1475-6374
1475-6366