Promising inhibition of diabetes-related enzymes and antioxidant properties of Ptilostemon casabonae leaves extract
Type 2 diabetes (T2D) is a progressive metabolic disorder of glucose metabolism. One of the therapeutic approaches for the treatment of T2D is reducing postprandial hyperglycaemia through inhibition of the digestive enzymes α-glucosidase and α-amylase. In this context, aimed at identifying natural p...
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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| 001 | doaj_aa394a58609849ec92d4e0dba336dc05 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Cinzia Sanna |e author |
| 700 | 1 | 0 | |a Antonella Fais |e author |
| 700 | 1 | 0 | |a Benedetta Era |e author |
| 700 | 1 | 0 | |a Giovanna L. Delogu |e author |
| 700 | 1 | 0 | |a Enrico Sanna |e author |
| 700 | 1 | 0 | |a Laura Dazzi |e author |
| 700 | 1 | 0 | |a Antonella Rosa |e author |
| 700 | 1 | 0 | |a Arianna Marengo |e author |
| 700 | 1 | 0 | |a Patrizia Rubiolo |e author |
| 700 | 1 | 0 | |a Antonio De Agostini |e author |
| 700 | 1 | 0 | |a Sonia Floris |e author |
| 700 | 1 | 0 | |a Francesca Pintus |e author |
| 245 | 0 | 0 | |a Promising inhibition of diabetes-related enzymes and antioxidant properties of Ptilostemon casabonae leaves extract |
| 260 | |b Taylor & Francis Group, |c 2023-12-01T00:00:00Z. | ||
| 500 | |a 10.1080/14756366.2023.2274798 | ||
| 500 | |a 1475-6374 | ||
| 500 | |a 1475-6366 | ||
| 520 | |a Type 2 diabetes (T2D) is a progressive metabolic disorder of glucose metabolism. One of the therapeutic approaches for the treatment of T2D is reducing postprandial hyperglycaemia through inhibition of the digestive enzymes α-glucosidase and α-amylase. In this context, aimed at identifying natural products endowed with anti-T2D potential, we focused on Ptilostemon casabonae (L.) Greuter, a species belonging to Asteraceae family. Enzymatic inhibition, antioxidant activity, phenolic composition and cellular assays were performed. This study revealed that the P. casabonae hydroalcoholic extract exerts a potent inhibitory activity against α-glucosidase. This activity is supported by an antioxidant effect, preventing ROS formation in a stressed cellular system. HPLC-PDA-MS/MS analysis, revealed a complex polyphenolic fraction. Among the tested pure compounds, 1,5-dicaffeoylquinic acid, apigenin and rutin displayed good α-glucosidase inhibitory activity. Our study suggested new potential of P. casabonae encouraging us to further testing the possible therapeutic potential of this extract. | ||
| 546 | |a EN | ||
| 690 | |a α-Glucosidase | ||
| 690 | |a α-amylase | ||
| 690 | |a diabetes | ||
| 690 | |a enzyme inhibition | ||
| 690 | |a Ptilostemon casabonae | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023) | |
| 787 | 0 | |n https://www.tandfonline.com/doi/10.1080/14756366.2023.2274798 | |
| 787 | 0 | |n https://doaj.org/toc/1475-6366 | |
| 787 | 0 | |n https://doaj.org/toc/1475-6374 | |
| 856 | 4 | 1 | |u https://doaj.org/article/aa394a58609849ec92d4e0dba336dc05 |z Connect to this object online. |