Discovery of a Novel Benzimidazole Necroptosis Inhibitor from an In-House Compound Library
Necroptosis, a caspase-independent regulated cell death, is primarily mediated by the serine/threonine kinases RIPK1 and RIPK3, and the mixed lineage kinase domain-like protein (MLKL). Targeting necroptosis is a validated therapeutic strategy for various diseases. We screened compound 1, a novel ben...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Georg Thieme Verlag KG,
2024-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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