Discovery of a Novel Benzimidazole Necroptosis Inhibitor from an In-House Compound Library

• Main Authors: Yu Zou (Author), Yue Chai (Author), Hongming Shao (Author), Shuyu Wang (Author), Ruilin Hou (Author), Runhui Liu (Author), Linjing Zhao (Author), Chunlin Zhuang (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Necroptosis, a caspase-independent regulated cell death, is primarily mediated by the serine/threonine kinases RIPK1 and RIPK3, and the mixed lineage kinase domain-like protein (MLKL). Targeting necroptosis is a validated therapeutic strategy for various diseases. We screened compound 1, a novel ben...